Aktivitas Antihiperurisemia Ekstrak Etanol Daun Lada (Piper nigrum L.) Pada Mencit (Mus musculus L.)
ABSTRACT: A study of pepper
leaves (Piper nigrum L.) ethanol extract anti-hyperuricemia activity in mice
has been done. The aim of this study was to know the effect of administration,
to look for the best dose and to know the potency of pepper leaves ethanol
extract in decreasing uric acid level of mice (Mus musculus L,). The method was
in vivo anti-hyperuricemia activity using potassium oxonate-induced
hyperuricemia mice. The mice were divided into 5 groups, i.e negative control,
positive control, extract dose of 12.5 mg/kg BW, extract dose of 25 mg/kg BW
and extract dose of 50 mg/kg BW. Each group consisted of 3 mice. The test
substances were given orally at 0.75 hours after the induction of potassium
oxonate then uric acid levels were measured at 1; 1.5; 2; 2.5 and 3 hours after
induction. Uric acid levels of mice were measured using a test-strip uric acid.
The results were analyzed visually by an average of the measured data and
graphs. The results showed that the pepper leaves ethanol extract dose of 12.5
mg/kg BW, 25 mg/kg BW and 50 mg/kg BW capable to inhibit the increase of uric
acid levels. The best dose was 25 mg/kg BW, but based on observation, it was
not better than the positive control allopurinol.
Penulis: Hardian, Riski
Sulistiarini, Laode Rijai
Kode Jurnal: jpfarmasidd140415
