QT dispersion, a simple tool to predict ventricular tachyarrhythmias and/or sudden cardiac death after myocardial infarction
Abstract: Recent studies showed
contradictive results of the relation between QT dispersion and the occurrence
of ventricular tachyarrhythmias and/or sudden cardiac death. In addition, beta
adrenoreceptors blocking agents, which are known to decrease the incidence of
lethal arrhythmias after myocardial infarction, administered to the majority of
patients in those studies population. Since β -blocker as secondary prevention
drug was underutilized at National Cardiovascular Center Harapan Kita, this
study was performed to find out the relation between QT dispersion and
ventricular tachyarrhythmias and/or sudden cardiac death after previous
myocardial infarction. The QT interval duration, QT dispersion and clinical
variables of 36 postinfarction patients with history of sustained ventricular
tachyarrhythmias and/or sudden cardiac death (event group) were compared with
75 postinfarction patients without such events (control group). QT dispersion
differed significantly between study groups and was increased in the event
group (115 ± 41 msec vs 81 ± 25 msec, p < 0.001). Corrected maximal QT
interval duration was also prolonged in the event group (534 ± 56 vs 501 ± 35
msec, p < 0.001). Regression analysis showed that increasing QT dispersion
was related to the occurrence of ventricular tachyarrhythmias and/or sudden
cardiac death with OR of 3.2, 4, and 5.8 for cut-off point of 80, 90, and 100
msec respectively. The QT dispersion
could predict the occurrence of ventricle tachyarrhythmias and/or sudden cardiac
death in patient with AMI. This study confirmed that the QTd remain useful in
free of beta blocking agents state.
Author: Yoga Yuniadi, M
Munawar, Budhi Setianto, Otte J. Rachman
Journal Code: jpkedokterangg050141
