Number of pre-treatment seizure as prognostic factor of convulsive epilepsy in childhood and young adult onset
ABSTRACT: Epilepsy is one of
the most common neurological disorders with complex problem. The role of number
of pre-treatment seizure is not conclusive yet. A historical cohort design was
conducted to evaluate the role of number of pre-treatment seizure as predictive
factor of remission. The subjects were epilepsy patients with onset 2-25 years
old with convulsive seizure manifestation that at least had taken medication
for 2 years. This study included 110 epilepsy patients, consisted of 42.7% male
and 57.3% female. Six months remission with 2 years medication were achieved in
86 patients (78.2%). The significant predictive factors for not achieving 6
months remission are seizure type, number of pre treatment seizure, and the
presence of neurological deficit. Twelve months remission were only achieved by
48 patients (43.6%). The significant predictive factors for not achieving 12
months remission were high number of pre-treatment seizure, the presence of
neurological deficit, and the incompliance of treatment program. The average numbers
of breakthrough seizure were significantly higher in patients with high number
of pre treatment seizure, presence of neurological deficit, partial type of
epilepsy, and non-compliance patients. Most epilepsy patient achieved6 months
remission with treatment, but only about half of them achieved 12 months
remission. High number of pre treatment seizure was significant poor predictive
factors for achieving remission. The strongest poor prognostic factors were the
presence of neurological deficit.
Author: Rizaldy Pinzona,
Harsono, dan Imam Rusdi
Journal Code: jpkedokterangg060004
