SYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS
ABSTRACT: UK-3A is secondary
metabolite of Streptomyces sp.517-02 which has IC50 38 µg/mL against P388
Murine Leukemia cells. An analogue of UK-3A was synthesized from L-methyl
serine as the starting material by amidation and esterification. An analogue
UK-3A was analyzed and identified by TLC, FT-IR, LC-MS and NMR spectrometer. It
was found to have IC50 15.4µg/mL against the same Leukemia cells. The overall
yield was 87.10%.
Author: Y Anita, M Hanafi, AMJ
Putra, S Arifin, Y Usuki, and H Iio
Journal Code: jpkimiagg070022
