Studi In Vivo Peranan Senyawa Fenolik Dalam Aktivitas Antihiperkolesterol Virgin Coconut Oil
ABSTRACT: The role of phenolic
compounds on antihypercholeserol activity of Virgin Coconut Oil (VCO) has been
investigated. The in vivo studies ware carried out by treatment of two groups
of Wistar white mouse (Ratus norvegicus) using high phenolic VCO and low
phenolic VCO respectively, followed by analysis of lipid profile in blood and
liver serum of the mouse. In addition a group of hypercholesterol mouse was
treated with low phenolic VCO and the blood serum lipid profile was compared
with untreated hypercholesterol mouse. The results show that phenolic compound
play an important role on antihypercholesterol of VCO. Group of mouse treated
with high phenolic VCO have better lipid profile (blood serum: total
cholesterol: 70 mg/dL, triglyceride: 76 mg/dL, HDL: 20 mg/dL, LDL: 35 mg/dL;
liver serum: total cholesterol:7 mg/dL, triglyceride: 19 mg/dL) compared with
the group treated with low phenolic VCO (blood serum: total cholesterol: 82
mg/dL, triglyceride: 100 mg/dL, HDL: 21 mg/dL, LDL: 41 mg/dL; liver serum:
total cholesterol: 9 mg/dL, triglyceride: 34 mg/dL). Hypercholesterol mouse
tests shown that low phenolic VCO treatment result in decreasing of blood serum
cholesterol level by 52.10% which was not significantly different compared to
untreated mouses (decreasing of blood serum cholesterol level by 48.61%).
Penulis: Tri Joko Raharjo,
Ariyani Setyo Widhiyati, Endah Mulya Asih, Sumiaty Sumiaty, Raden Tambunan, Ani
Setyopratiwi
Kode Jurnal: jpkimiadd080107
