Sintesis Turunan Isoquino[2,1-c][1,3]Benzodiazepine Dari Papaverine
ABSTRACT: The objective of
this research was to synthesize isoquino[2,1-c][1,3]benzodiazepine from
papaverine alkaloid. Functional Group Interconversion (FGI) and Carbon
-Nitrogen bond connection approach was investigated. Papaverine (1) was
nitrated by HNO3 to compound (2) and followed by reduction with Sn and HCl to
afford aminonorlaudanosine (3). Formation of cyclic benzodiazepine (4) was
achieved by reaction of (3) with CS2. Products of reactions were confirmed by
Nuclear Magnetic Resonances (n.m.r), Mass Spectrum, and Fourier Transform Infra
Red (FTIR).
Penulis: I Made Sudarma, John
Bremner
Kode Jurnal: jpkimiadd070102
