STUDI SISTEM DISPERSI PADAT ISOXSUPRINE HCL POVIDON K-30
ABSTRACT: A study on Solid
Dispersion System of Isoxsuprine HCl by using syntetic polymer Povidon K-30 to
increase solubility has been done has been done. The solid dispersion system
were prepared by using solvent method with any comparison ( Taslim, 2007).
Charactheristics of physical chemistry properties of solid dispersion such as
dissolution test, X-ray diffraction analysis,
Differential Scanning Calorimetry,
and Fourier Transform
Infra Red were assayed.
The dissolution test
from solid dispersion
by using UV
spectrophotometer. Statistical analysis of solid dispersion’s
dissolution test was done by using Anova.
The characteristic X-ray’s diffraction and FTIR showed that
solid dispersion with drug to polimer
ratio of 1:9
; 2:8 ;
3:7 were amorf
in comparison to
other solid dispersions. Statistical analysis
by one direction
Anova concluded that
the dissolution profile
of the solid dispersion system of
2:8 was the highest.
Penulis: Tuty Taslim ,Auzal
Halim, Muslim Suardi
Kode Jurnal: jpfarmasidd100038
