Preparasi, Karakterisasi dan Evaluasi Pelepasan Obat dari Beads Kalsium Alginat Deksametason dengan Metode Gelasi Ionik
Abstract: Inflammatory Bowel
Disease (IBD) is a disease of inflammation in the colon. Targeted delivery
systems for the treatment of IBD is designed to increase the drug concentration
in the local tissue. Dexamethasone is a drug having anti-inflammatory and
antifibrosis effects which is used to repair scar tissue arising from
postoperative IBD. This research purpose to create calciumalginate beads
dexamethasone to be released only in the colon. Beads were made by using
sodium-alginate and Ca2+ as crosslinker by ionic gelation method, with ratio
between sodium alginate-dexamethasone (3:1). A concentration of solution sodium
alginate 3 % b/v with variation concentration of crosslinker is 2% (formula 1),
3% (formula 2), and 4% (formula 3). Beads were characterized and drug release
determined. The results obtained were spherical beads with a size range between
630 > 800 µm with the greatest encapsulation efficiency obtained from the beads
formula 1 with the amount of 98.14% and after coated with Eudragif ® S100 using
a fluid bed dryer apparatus, beads of formula 4 was obtained with an
encapsulation efficiency of 67, 78%. Beads formula 1 were only released in
stomach pH and not able to hold up the release of the active substance in
colonic pH, whereas beads of formula 4 releasing dexamethason gradually more
than 8 hours in colonic pH, and has a better release profile for the active
substance.
Keywords: Calsium-alginate
beads; colon drug delivery system; dexamethasone; eudragit ®S100; ionic
gelation
Penulis: C. Aulia
Kode Jurnal: jpfarmasidd120149
