OPTIMASI METODA ISOLASI KATEKIN DARI GAMBIR UNTUK SEDIAAN FARMASI DAN SENYAWA MARKER
ABSTRACT: Optimization studies
out on isolation
of catechin from
gambier and pasta
for the pharmaceutical and
marker compounds have
been carried. Gambier
gambier and paste were
obtained from the
Medicinal Plant Garden
Andalas University, Siguntur
and Lima Puluh Kota.
Isolation method used
was non-purification method,
pre-purification for gambier and
fractination for pasta.
The analysis performed
included catechin solubility, melting point,
maximum absorption, thin-layer
chromatography, loss on
drying, ash content, yield and
determination of levels of catechin. Product which has the highest levels of
catechins, the determination was
continued by analysis of UV spectra and NMR. The best results
for pharmaceuticals derived
from Siguntur with
pre-purification methods which resulted
in yield 56.3%
with 96.17% catechin
content, whereas for
a marker compound was
obtained from gambier
Siguntur pasta with
fractionation method which yielded 12.13% with 97.96% of catechin
level.
Penulis: Noveri Rahmawati,
Amri Bakhtiar, Deddi Prima Putra
Kode Jurnal: jpfarmasidd110094
