Formulasi Sediaan Gel Niosom Kafein dan Usaha Peningkatan Absorpsi melalui Kulit
Abstract: Cellulite is a
condition in the skin that changes the topographic of the skin surface.
Caffeine can be used as an active compound for its slimming effect. To improve
the penetration into the skin and increasing its solubility for cellulite
treatment, caffeine was formulated as niosome vesicles. Niosome was made by
using thin layer hydration method. Span 60, caffeine and cholesterol dissolved
in chloroform and evaporated to produse a thin layer. The dispersion of
caffeine and niosome was formulated in the form of gel using 6% of HPMC gel
base. To determine the formulation stability, caffeine niosome gel was stored at
a room temperature and accelerated condition using climatic chamber at a
temperature of 40⁰C, 75% RH for 28 days. The result was then compared with
caffeine gel. The diffusion rate of both gels was determined in vitro using
flow through method. The results showed that the niosome system improved the
solubility of caffeine up to 20,34 mg/ml and also showed that the pH and
viscosity of caffeine niosome gel were stable under room temperature and
accelerated condition.The diffusion test showed that the flux of caffeine
niosome gel is 13.991 μg/cm2
Penulis: Rahma Nafi'ah,
Sasanti Tarini Darijanto, Diky Mudhakir
Kode Jurnal: jpfarmasidd140116
