ANALISIS ASPEK FARMAKOKINETIKA KLINIK PASIEN GAGAL GINJAL PADA IRNA PENYAKIT DALAM RSUP DR. M. DJAMIL PADANG
ABSTRACT: A study on the
evaluation of clinical pharmacokinetic aspect to in-patient with renal ailure at
internal Ward Dr. M. Djamil
hospital Padang has
been conducted. The
aspect studied was dosage
individualization bades on
patient’s patophysiological condition.
The study aimed at
comparing the dosage
regimen given to
the renal failure
patient with that calculated using
pharmacokinetic equations. This
study was observasionaly prospective
by using cross-sectional method.
In the period
of June –
September 2010, 48
renal failure patients includes
in inclusion criterion. Results showed that medications which mainly renal excreted or
potentially nephrotoxic given
to patients are
ciprofloxacin, digoxin, ranitidin, metformin, captopril,
furosemide and hydrochlortiazide. Patients
treated with those medications were evaluated in terms of
dosage regimens and clinical response. There were 4 cases of higher dose than
recommended included 1 of 8 cases of captopril use, 2 of 9 cases of ciprofloxacin
use and 1 of case of metformin use. It uses also found that hydrochlortiazide which
should be avoided to patients with Clcr < 30 ml/min (4 cases)
Penulis: Henny Lucida, Riah
Trisnawati dan Muslim Suardi
Kode Jurnal: jpfarmasidd110091
