SINTESIS SENYAWA ANTIMALARIA BARU TURUNAN FENANTROLIN N-(2-NITROBENZIL)-1,10-FENANTROLINIUM IODIDA DAN (1) N-(4-NITROBENZIL)-1,10-FENANTROLINIUM IODIDA
ABSTRACT: Malaria is a global
health problem, especially in the tropics. Efforts to decrease the incidence of
malaria plagued the plasmodium resistance to existing antimalarial drugs.
Benzyl Phenanthrolium Iodide derivates have been proved has antimalarial
activity. The aim of this study is synthesis the nitro benzyl phenanthrolium.
The research that has been done was the synthesis of
(1)-N-(2-nitrobenzyl) phenantrolium iodide
and(1)-N-(4-nitrobenzyl)-1,10-phenantrolium iodide. Synthesis of
(1)-N-(2-nitrobenzyl)-1,10-phenantrolium iodide through a two-steps reaction
SN-2 is the reaction of (1)N-(2- nitrobenzyl) chloride and potassium iodide
followed by reaction phenantroline 1:10 monohydrate, whether the second product
was 4-nitrobenzil bromida as starting material. The reaction were started by
reflucting the nitro subtituted benzil halida with potassium iodide for 1 hour,
yielded nitro subtituted benzyl iodide. Then followed by reflucting nitro
substituted benzyl iodide with 1,10-phenanthroline for 11 hours. The final
product isolated and purificated by suitable solvent. The melting point was
conducted by melting poin apparatus. The structures of product was
characterized by IR and UV-Vis spectroscopy.
Results obtained in the form of thick liquid light yellow with a melting
point of 54.2-63.5oC. While the compound (1)-N-(4-nitrobenzyl)-1,10-phenantrolium
iodide is synthesized from 4-nitrobenzylbromide and potassium iodide followed
by reaction phenantroline 1:10 monohydrate. Synthesis results in the form of
pale yellow crystals with a melting point of 221–225oC . The resulting yield
of 32.87%. The interpretation of UV-Vis and Infra red spectras indicated that
nitro benzyl iodide have been condensed with 1,10 phenantroline as the end of
the product.
Penulis: Dwi Utami, Iin
Narwanti, Jumina
Kode Jurnal: jpkimiadd140009
