PENGARUH PEMBERIAN PERASAN PARE TERHADAP PROFIL LIPID SERUM TIKUS WISTAR
Abstract: Momordica charantia
(MC) has anti-atherogenic effect that hoped may repair the blood lipid profile (BLP).
The research design was randomized post-testcontrol group of 30 male Wistar, 20
weeks, health, fed with standard diet, drink water ad libitum, divided randomly
into six groups. Group I and II only fed with standard food and egg yolk for
three and six weeks.Group III and IV fed with only MC juice for three and six weeks.
Group V and
VI fed with
egg yolk and MC juice
for three and
six weeks. The
BLP (total cholesterol, HDL,
LDL, triglyceride) were
measured by enzymatic
methods. The mean
data were compared with
Kruskall Wallis and
Mann Whitney tests,
by SPSS 12.0.
The highest mean
of total cholesterol in Group II
(251,1±5,8), the lowest in Group IV (116,5±6,6). The highest mean of HDL in
Group V (100,1±3,5), the lowest in Group IV (59,1±5,2). The highest mean of LDL in Group II
(117,9±1,1), the lowest in Group
III (30,8±0,7). The
highest mean of
triglyceride in Group
II (205,8±5,1), the
lowest in Group IV
(118,4±5,9). The Kruskal
Wallis test for
total cholesterol was
p<0,0001, HDL p=0,001,
LDL p<0,0001,
triglyceride p=0,001. The
Mann-Whitney U test between
Group I vs
III have significantly differences in total
cholesterol total, LDL, (p=0,009); Group II vs IV have significantly
differences in total cholesterol, HDL,
LDL, triglyceride, (p=0,009);
Group III vs
IV have significantly
differences in total cholesterol, HDL,
LDL, and triglyceride
(p=0,009); Group V
vs VI have significantly differences
in total cholesterol and HDL
(p=0,009); Group III vs V have significantly differences in total cholesterol,
HDL, LDL, triglyceride (p=0,009); Group
IV vs VI
have significantly differences
in total cholesterol,
HDL (p=0,009). The MC juice may
decrease the LDL, total cholesterol, and triglyceride, increase the HDL. There
was a trend of decreasing
in BLP for
6 and 3
weeks dietary. There
was significantly difference
in total cholesterol, HDL, LDL
between Group with MC juice only.
Penulis: Arina Maliya dan Arum
Pratiwi
Kode Jurnal: jpkesmasdd080005
