Perbedaan Kadar Resistin Pada Obes Dengan Resistensi Insulin Dan Obes Tanpa Resistensi Insulin
Abstract: Resistin is an
adipocytokine that secreted from adipose tissue, resistin level serum increased
in obese patients. Resistin has important biological activity on glucose and lipid
metabolism, and can affect insulin resistance. Previous study suggested that
high level resistin can induce insulin resistance and has contribution to
impaired insulin sensitivity. The Objective of this study is to know
differences of resistin level in obese with insulin resistance and obese
without insulin resistance. This is a cross sectional study with obesity patients recruited from General
Check Up and Endorinology outpatients clinic Sardjito General Hospital
Yogyakarta. Obese patients are subjects with body mass index (BMI) ≥ 25 kg/m2.
Insulin resistance was assessed using HOMA-IR (homeostasis model assessment
insulin resistance), formula calculated from fasting insulin and glucose
levels. Resistin was measured with ELISA technique. Differences
of obese with insulin resistance and obese without insulin resistance analyze
using Mann Whitney U test. There was 48 subjects analyzed in this study, 24 obese patients
with insulin resistance and 24 obese patients without insulin resistance. Mean of
resistin level was higher in obese subject with insulin resistance than without
insulin resistance, but there was no significant (27,65±14,44 ng/ml vs
23,99±12,45 ng/ml, p= 0,37). From this research, it can be concluded that
Resistin level in obese with insulin resistance higher than obese without
insulin resistance, but no significant.
Penulis: Erlina Marfianti
Kode Jurnal: jpkedokterandd090012
