Perbandingan Pengaruh Ozon, Getah Jarak Cina (Jatropha MultifidaL.) dan Povidone Iodine10% terhadap Waktu Penyembuhan Luka pada Mencit Betina Galur Swiss Webster
Abstract: Unlike the popular
povidone iodine 10% and the effective Jatropha multifida L. latex, ozone has been
used as an alternative wound healing therapy for a long time but the advantage
is still controversial. The aim of this research is to compare the effect of
ozone, Jatropha moultifida L. latex and povidone iodine 10% on the wound
healing process. The experiment used a Random Complete Design with comparative characteristics.
The animal models were 24 adult Swiss Webster female mice, divided into 4
groups (n=6). The thighs of the mice were shaved before an 8-mm slice on the
skin was made. Group I had no treatment, group II was treated with
povidoneiodine 10% topically, group III with ozone and and group IV with Jatropha
multifida L. latex. The treatment and the wound length measurements were
carried out every day until all the wounds were healed. The result showed that
the average time span of wound healing of each of groups I, II, III, and IV was
subsequently 6.80 days, 6.88 days, 4.17 days, and 5.83 days. The time span of the
healing process in the 3rd (ozone) group was very significantly different from that of the negative control
group (p=0.001) and it was significantly different from that of
Jatrophamultifida L. latex group (p=0.0032). The time spans of the healing
process of group II (povidone iodine 10%) and group IV (Jatropha multifida L.
latex) were not significantly different from that of the negative control group
(p=0.364). The conclusion is thatozone significantly accelerates the wound
healing process more than Jatropha multifida L. latex and povidone iodine 10%.
Penulis: Alvina Dewiyanti,
Hana Ratnawati, Sugiarto Puradisastra
Kode Jurmlah: jpkedokterandd090082
