Perbandingan Efek Analgesik antara Parasetamol dengan Kombinasi Parasetamol dan Kafein pada Mencit
Abstract: Paracetamol is
derived from paraaminofenol which have light to medium analgesic effect. This medicine often combine with caffeine
that can produce analgesic potential by blocking prostaglandin synthesis.
Single dose caffeine has vasoconstrictor effect to central blood circulation
and vasodilation on peripheral blood circulation. This research was done to
find out that the combination of paracetamol with caffein have higher analgesic
effect than analgesic effect of paracetamol only. This research used 30 mouses
which age between 2-3 months and 25-30 gram body weights, to prove that
caffeine can make analgesic effect stronger than paracetamol only. Before
intervention, subject was treated to find the average critical point for
painful sense, about 43.5°C. After that, subject was treated by homogenity
treatment and by devided to 2 random group. Group I were injected by paracetamol by
intraperitoneal method which have dose 1.30mg/10g.BW. The second group were
injected by the combination from paracetamol with caffeine with each dose each
is 1.30mg/10g.BW.and 0.52mg/20g.BW. by intraperitoneal method. Than mouses were put into hot plate and observed
how many times they starled in every 5 minutes periode. This research result
is: average amount the mouses strarled for group I is 68.867 and this result is
higher than average amount the mouses strarled for group II which only 51.933. With t test we can find out that t empirical
(to=3.787) this number is bigger than t theorical or t table with significantly
1% (tt=2.756). From this statistic we can find out that average amount the
mouses strarled for group II is lower than group I and it's significantly
different. According to this research, it can be concluded that analgesic
effect of the combination paracetamol with caffeine is higher than analgesic
effect paracetamol only.
Penulis: Aris Gunawan
Kode Jurnal: jpkedokterandd090059
