Gizi Kurang sebagai Faktor Risiko Hepatitis Drug Induced karena Obat Anti Tuberkulosis
Abstract: Some anti
tuberculosis drugs were used in combination to treat tuberculosis. Appropriate
therapy shows good outcome, however, anti tuberculosis drugs can cause
hepatotoxicity. The previous study suggests that malnutrition is a risk factor
of Drug Induced-Hepatitis (DIH). Objective of this study was to determine
whether moderate malnutrition is a risk factor of DIH among children treated
with anti-tuberculosis drugs. In this study, a case-control study was conducted
among children treated with anti-tuberculosis drugs. Data were obtained from
medical record of outpatient and inpatient of pediatrics patients from January
2001 to November 2006 in 6 hospitals. DIH is defined as elevated serum
transaminase 5 times more than normal, elevated bilirubin level more than 1,5
mg/dl or any elevation of transaminase serum with clinical symptom such as
icteric. Patients meeting the inclusion criteria were included in the study and
those meeting the exclusion criteria excluded from the study. Then data were
followed retrospectively to see the nutritional status at the starting point of
therapy. The Odds Ratio (OR) of nutritional status determine using chi square
analysis. There were 31 children diagnosed as DIH, 2 were excluded from the
study because of phenytoin and carbamazepin therapy. There were no significant
differences on age, gender, and moderate malnutrition. Only severe malnutrition
was had significant difference with OR 3,2 (95% CI 1,13 9,2; p = 0,023). Malnutrition is not a risk
factor while severe malnutrition is a risk factor of DIH among children treated
with anti tuberculosis drugs.
Penulis: Rusmawati; Roni
Naning; Djauhar Ismail
Kode Jurnal: jpkedokterandd090060
