Pengaruh Pemberian Ekstrak Buah Merah (Pandanus conoideus Lam.) terhadap Aktivitas Fagositosis Makrofag
Abstract: The immune system
has an important role in human health. The innate immune-system defends the
host against infection by phagocytes the antigen, which is the role of
macrophage cell. Red Fruit (Pandanus
conoideus Lam.) had been empirically proved to increase body immune system. The
aim of this study is to know the effect of Red Fruit toward the macrophage’s
phagocytotic activity.
This research was acted invitro on Swiss Webster mice’s macrophage cell
culture, which was exposured by Red Fruit extract (concentration 0,25ug/dl;
0,50ug/dl; 1,00ug/dl; 2,50ug/dl; 5,00 ug/dL) in 5’, 10’, 30’, and 60’. The
percentage of activated macrophages was counted, compared between treatment
group and negative control group (aquadest). The data was processed by One Way
Anova and Tukey HSD statistical methods.
The result shows that 10’, 30’ and 60’ exposured of Red Fruit extract
could increase Macrophage’s activity significantly (p=0,000). The optimal dose
of Red Fruit extract which could increase the activity of macrophage is 0,25
µg/dl. With 10’, 30’ and 60’ exposured of Red Fruit could increase the
phagocytotic activity of macrophages 76.15%
ug/dl, 65.32% ug/dl, and 83.41%
ug/dl.
It can be concluded that the exposurd of Red Fruit extract 10’, 30’ and
60’ could increase macrophage’s phagocytotic activity, with the optimal dose is
0,25 µg/dl.
Penulis: Hana Ratnawati, Yudhi
Handoko, Leonard H. Purba
Kode Jurnal: jpkedokterandd0700148
