Pengaruh Kombinasi Ekstrak Umbi Lapis Bawang Putih dan Ekstrak Rimpang Kunyit terhadap Janin Mencit Swiss-Webster
Abstract: The influence of
solution of garlic (Allium sativum L.) in water and solution of turmeric
(Curcuma domestica Val.) in ethanol had been studied in pregnant Swiss-Webster
mice. The garlic and turmeric extract were administered orally at dose level
combination of 100:100, 500:500, and 1000:1000 mg/kg body weight on day sixth
to fifteenth of gestation. The mother was sacrified on day eighteenth day of
gestation to observe life fetus, resorption, and growth failure. One third of
the fetuses were eviscerated for skeletal staining with alizarin red and two
third of the fetuses were hardened with Bouin’s fixation solution. No
malformation were found in the eviscerated group. Resorption of 1.11 % fetuses
and 1.11 % growfail fetuses showed by extract combination of 100:100 mg/kg body
weight. Growfail Growth failure of 4.59
% fetuses showed by extract combination of 500:500 mg/kg body weight.
Resorption of 0.96 % fetuses showed by extract combination of
1000:1000 mg/kg body weight. The conclusion of this study, is that the
combination of turmeric and garlic extract of 100:100 mg/kg body weight, which
is equivalent to usual dose in human showed safe as herbal medicine, while in
higher dose it is not recommended for pregnant woman.
Penulis: Elin Yulinah
Sukandar, Irda Fidrianny, Afrillia Nuryanti Garmana
Kode Jurnal: jpkedokterandd080029
