Model Indeks Peroksidatif dan Indeks Protein Teroksidasi Saliva Penderita Tuberkulosis Paru Berdasarkan Lama Pengobatan

Abstract: Mycobacterium  tuberculosis  in  human  may  induce  a  variety  of  responses  involving  protective immunity  to  clinical  manifestation  of  tuberculosis.  Oxidative  mechanism  to  infection  controlling  can happen not only in macrofag but also in all liquid compartments of the body. The objective of this study is to  evaluate  peroxidative  index  and  Advanced  Oxidation  Protein  Products  (AOPPs)  in  tuberculosis patients’ saliva at a treatment period. The tuberculosis patients  were grouped according to the length of treatment,  P0=0-1  months,  P1=1-3  months,,  P2=3-5  months,  and  P3=5-6  months.  Peroxidative  index and  Advanced  Oxidation  Protein  Products  (AOPPs)  at  P0  were  very  high  but  then  they  decreased progressively  in  P,  P2,  and  P3.  Peroxidative  index  and  AOPPs  are  potential  as  detectors  of  oxidative mechanism in tuberculosis treatment. The correlation treatment period and peroxidative index model y=-127,08x3+ 1651, 7x2– 6692,6x + 8571 (R2= 1).  The correlation treatment period and AOPPs model y = -0,0398x + 0, 4479 (R2= 0,8073).
Key words: hydrogen peroxide, peroxidative, AOPPs, saliva
Penulis: Eko Suhartono, Bambang Setiawan
Kode Jurnal: jpkedokterandd100056

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