Efek Hipnotik Biji Seledri (Apium Graveolens L.) pada Mencit Jantan Galur Ddy dan Pengaruhnya terhadap Waktu Reaksi Sederhana (WRS) pada Manusia
Abstract: People in their
lifes have ever experienced sleep disorder (insomnia). In order to overcome
sleep disorder pharmacologically, hypnotic sedative drugs can be administered.
These drugs have hazardous side effects such as habituation, tolerance, and
addiction. Traditional medicines can be used as an alternative hypnotic
sedative drugs which have less side effects, and one of them is celery seed
(Apium graveolens L.).
The aims of this research are to determine the hypnotic effect of celery
seed and its influence on simple
reaction time.
The method used in this research was by testing the water
extracted-celery seed with various dose on DDY strain male mice. These mice
were inducted by Phenobarbital. The measured data were the onset and the
duration of sleeping time compared with control. The measurements of simple
reaction time was done with red, yellow,
green, and blue light on 10 research subjects, before and after ingestion of
water extracted- celery seed.
These results suggest that the onset of mice sleeping time with 4 human
dose (4 HD) of water extracted-celery seed doesn’t significantly different with
Diazepam, but its duration is different (the same as control). The measurements
of simple reaction time on human suggest that celery seed can prolong the
duration. In addition it also celery seed prolong the simple reaction time on
human.
Penulis: Sugiarto
Puradisastra, Rosnaeni, Iwan Budiman
Kode Jurnal: jpkedokterandd0700154
