ANGIOGENESIS: Patofisiologi dan Aplikasi Klinis
Abstract: Angiogenesis is
a process of new
blood vessel development from
pre-existing vasculature. The process
plays an essential
role in the
normal growth of tissues,
wound healing, tissue
regeneration following
cardiovascular events, and
even during female
reproductive cycles (i.e.
menstruation and placental development).
Under these conditions,
angiogenesis is highly
regulated by angiogenic
factors. Several angiogenic factors,
such as Vascular
Endothelial Growth Factor
(VEGF), Fibroblast Growth Factor (FGF), Transforming Growth
Factor (TGF), and angiopoietin, have extensively been studied and have been
used to treat many diseases. However, persistent unregulated angiogenesis has
also been shown to contribute to many diseases such as tumor metastases,
rheumatoid arthritis, and diabetic retinopathy. Continued advances
in understanding the
mechanism of the
angiogenic process may
provide further diagnostic and
therapeutic benefits in dealing with a variety of diseases.
Penulis: Frisca, Caroline T.
Sardjono, Ferry Sandra
Kode Jurnal: jpkedokterandd090089
