ABSTRACT: The synthesis of
N-4t-butyl benzoil-p-aminophenol
has been done by reacting p-aminophenol and
N-4t-butyl benzoil chloride
compounds, then the products were isolated and
analyzed by TLC, melting
point determination, UV/Vis
Spectrofotometry, infra red spectrofotometry and mass spectrometry. The synthesis yield of
N-4t-butylbenzoil-p-aminophenol was 33,52%, with the compound melting point
between 192-194oC The
determination of analgesic
(ED50 of %
analgesic activity) and
anti inflammatory activity (ED50
of edema inhibition)
gave the ED50
of % analgesic
activity was 144 mg/kg and ED50 of % edema inhibition was 43,24 mg/kg.
Keywords: Synthesis,
N-4t-butyl benzoil-p-aminophenol compound, analgesic activity, antiinflammatory
activity
Penulis: Sri Sutji Susilowati,
Santi Nur Handayani
Kode Jurnal: jpkimiadd060023
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