GAMBARAN HISTOLOGIS HEPAR MENCIT (Mus musculus L.) STRAIN DDW SETELAH PEMBERIAN EKSTRAK N-HEKSAN BUAH ANDALIMAN (Zanthoxylum acanthopodium DC.) SELAMA MASA PRA IMPLANTASI DAN PASCA IMPLANTASI
Abstract: Liver histological
features of DDW
mice (Mus musculus
L.) treated with
n-hexane extract of
Andaliman (Zanthoxylum acanthopodium DC.) fruit during pre- and
post-implantation has been studied in Laboratory of Animal Structure,
Department of Biology,
Faculty of Mathematics
and Natural Science,
University of Sumatera Utara,
Medan. Experiment used
completely randomized design
(CRD) consisted of
2 periods of treatment: pre-implantation (day 0-3; group
A) and post-implantation (day 6-14; group B). For each group, mice were treated daily by oral gavage with
0, 1, 2, 4, or 6 % of andaliman extract in 0.3 ml of 1% CMC. The result
showed, liver in
treatment groups was
pale and showed
mottled surface texture.
Hepatocyte damage in post-implantation group was higher than in pre
implantation group (p> 0.05). We concluded that n-hexane extract of
andaliman fruit appears to negatively affect liver histology of mice.
Keywords: liver histology,
andaliman (Zanthoxylum acanthopodium DC.),
post implantation, pre implantation
Penulis: Eka Prasetiawan,
Emita Sabri dan Syafruddin Ilyas
Kode Jurnal: jpbiologidd120013
