UJI PERBANDINGAN EFEKTIVITAS ANTIDIABETES EKSTRAK POLISAKARIDA DAN SENYAWA POLIFENOL ALGA COKLAT (Sargassum sp.) PADA MENCIT YANG DIINDUKSI ALOKSAN
Abstract: Diabetes is one of
the most common diseases in the world. So there is an effort to prevent or
treat the disease. As brown algae (Sargassum sp.) Contains polysaccharides that
regulate sugar intake in the body, and polyphenols act as antioxidants that can
stimulate insulin secretion in pancreatic β cells. This study aims to determine
the effectiveness of Antidiabetes Polysaccharide Extract and Brown Algae
Polifenol Compounds (Sargassum sp) On Alloxaninduced Mice. The test animals
were grouped into 4 groups I (CMC 1%), Group II (Glibenclamide 0.52mg /
20grBB), Group III (5mg / 20grBB polyphenol extract), Group IV (5mg / 20grBB
polysaccharide extract). Blood glucose was measured using Easy touch glucometer
on days 0, 3, 7, 14, 21, and 28. Analyze data using one-way ANOVA, followed by
LSD test. The percentage decrease in blood glucose level in positive control,
polyphenol extract and polysaccharide were 42,86%, 58,12%, and 54,20%.
Statistically, the polyphenolic extract and the brown algae polysaccharide
lower the blood glucose level significantly compared with the negative control
(p≤0,05). Decreased blood glucose in polyphenol extracts and polysaccharides
showed statistically significant differences
Keywords: Brown Algae
(Sargassum sp.), Antidiabetic, Polyphenols, Polysaccharides
Penulis: Agung Giri Samudra, Fathur
Sani K, Moniq Chintama
Kode Jurnal: jpfarmasidd180037
