UJI MUTU FISIK GRANUL EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTAB®
Abstract: Bad breath is
usually caused by bacteria and food debris left in the mouth. Development of
preparations using herbal ingredients, to overcome the problem of bad breath
one of them is with utilization basil leaves (Ocimum americanum L.) which have
anti bacterial activity. The method of wet granulation is a single method for
use in granulation of large doses of active substances because if using direct
induced method will require again the addition of a large number of fillers to
make it easier forging, but cause the tablet to be not feasible as it will
resulting in an increase in tablet size. The type of research conducted is an
experimental study. Object the study was basil leaf extract formulated. This
formulation was prepared by wet granulation method with variation Explotab® ss
crusher ie 2%, 4%, 6% and 8%. Performed wet granulation on each formulation.
Granul evaluated the flow time, mass density test, silent angle and fixed assay
test. Based on research result the physical quality of ethanol extract granule
of basil leaves (Ocimum americanum L.) with explotab® concentration variation
it can be concluded that all the formula fulfill the good quality of granule
characteristic, because it meets the requirements of parameters of time flow,
rest angle, compressibility and density mass
Keywords: Basil leaves ethanol
extract (Ocimum americanum L.), Explotab®, wet granulation
Penulis: Yulistia Budianti
Soemarie
Kode Jurnal: jpfarmasidd170119
