Uji Daya Antelmetika Ekstrak n-Heksan Rimpang Bangle (Zingiber cassumunar) pada Cacing Ascaris suum secara In Vitro
Abstract: The objective of
this research was to investigate the anthelmentics activities of Zingiber
cassumunar rhizome n-hexane extract against Ascaris suum in-vitro. The
experiments were carried out by using immersion method. The worm were soaked in
extract of Zingiber cassumunar rhizome . One hundred and forty four ascaris
worms were divided into 8 groups; each Petri contain 6 wors of Ascaris suum the
dosage in every Petridish was 1 x LD50 (15,78 mg/100 ml), 2 x LD50 (31,56
mg/100 ml), 4 x LD50 (63,12 mg/100 ml), 8 x LD50 (126,24 mg/100 ml) and 12 x
LD50 (189,36 mg/100 ml). The positive control used was pirantel pamoat 250
mg/100 ml and as negative controls were solutions like intestine and carboxy
methyl cellulose 0,94% suspension. Experiment result shows that dosage 5
(189,36 mg/100 ml) was the most optimum dosage for anthelmentics treatment in
that dosage 27,8% Ascaris suum were dead. Anthelmentics investigation was done
by counting the deaths of Ascaris suum which were emmersed for 24 hours. The
infusion of zingiber cassumunar has strongest activity as anthelmentics rather
than in alcohol and n-hexane extract forms.
Keywords: Herbs anthelmintic;
n-hexane Zingiber cassumunar extract; Zingiber Cassumunar activity; Ascaris
suum
Penulis: Maratu Soleha, Anny
Victor Purba
Kode Jurnal: jpfarmasidd130416
