UJI AKTIVITAS HIPOLIPIDEMIK EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) PADA TIKUS OBESITAS DENGAN PARAMETER TRIGLISERIDA
Abstrak: Hypolipidemics a drug
used to lower plasma lipid levels in the blood. This study aimed to examine the
hypolipidemic activity of ethanol extract of purslane herb (Portulaca oleracea
L.) against the triglyceride level reduction in obese mice. The purslane herb
contains omega-3, flavonoids and hight ascorbic acid as a lowering of
triglyceride levels in the blood. This study used 15 malerats divided into 5
groups. Group I (negative control) was given Na.CMC 1%, group II (positive
control) was given Gemfibrozil, group III, IV, and V were given ethanol extract
of purslane herb with dose of 100 mg/kgBW, 200mg/kgBW, and 300 mg/kgBW as
therapy group. All the administration were done orally once a day for 16 days.
The measurement of triglyceride level was performed on early triglycerides
before induction, after induction and after therapy. Before therapy, the rats
were given hight-calorie diet. The results showed that the ethanol extract of
purslanes herb has activity as hypolipidemic in lowering trygliseride level in
obese mice. From the statistic result of One-Way ANOVA followed by LSD test, it
can be concluded that the ethanol extract of purslane herb of the dose 100
mg/kgBW provide the most effective hypolipidemic activity that triglyceride
level is not significantly different from positive control group (p>0,05).
Kata Kunci: Hypolipidemic,
purslane herb (Portulaca oleracea L.), triglycerides
Penulis: Rizqi Nur Azizah,
Bayu Putra, Rafika Tobis
Kode Jurnal: jpfarmasidd180150
