UJI AKTIVITAS EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG MENCIT PUTIH JANTAN (Mus musculus)
Abstract: Areca seeds contain
flavonoid, tannin, and alkaloid which can help the healing process of burn
wounds on the back skin of mice. Areca seeds are used for treatment because it
has antimicrobial activity. Areca Seeds
are one of Indonesian plants which the fruit in tranditional way is used as
burn medicine. The objective of this study was to know theeffect of ethanol
extract of areca seeds against burn wound healing on the back skin of mice.
Fifteen mices were used in this experiment and were divided into 5 groups :
vaseline flavum as a control negative, branded ointment as a control positive ,
ethanol extract of areca seeds in vaseline flavum with consentration 20%, 40 %
and 60 %. Each group consisted of 3 mices. The back skin of mice was induced
using hot iron size 1×1 cm for 2 seconds then given a treatment for 14 days.
The percentage of healing of burns by
calculating the surface area of wound. The results of its preliminary
phytochemical analysis showed the presence of alkaloids, flavonoids, tannins
and saponins. The percentage of burn wound healing of ethanol extract in
concentration 20 % was 84,33 %, 40 % was 87,67%; and 60% was 89,67%. Data was
analyzed using one-way Analysis of Variance (ANOVA) which showed that data has
significant differences (P < 0,05) was 0,000. LSD test showed that each
treatment group had siginicant differences with significant value <
0,05.
Keywords: Areca catechu, burn wound, wound surface area
Penulis: Fitri Handayani, Reksi
Sundu, Henriko Nober Karapa
Kode Jurnal: jpfarmasidd160460
