Uji Aktivitas Antidiabetes Ekstrak Etanol dari Akar dan Batang Tumbuhan Sekunyit (Fibraurea Tinctoria Lour)
Abstract: Sekunyit (Fibraurea
tinctoria Lour) is a species plant that has been used as traditional medicine
for treating several diseases including jaundice, dysentery, headache, eye
infection as well as anti diabetic drug. This research aims to evaluate
antidiabetic activity of ethanol extract of roots and stem of sekunyit on white
male mice (Mus musculus L) using glibenclamide as positive control. The
experimental animals were induced with alloxan 175 mg/Kg BW i.p and devided
into six groups, each group consisted of five mice. Group one served as
negative control which was given NaCMC 1%, group second was positive control,
given glibenclamide 0,65 mg/KgBW, while
group third, fourth, fifth were administered orally with etanol extract with
doses of 100, 200 and 300 mg/KgBW, respectively. The observed parameter were
measurement of blood glucose levels, urine volume and volume of drinking water
as well as ratio of relative organ weight. The treatment was conducted for 15
days. The result showed that administration of ethanol extract of roots and
stem of sekunyit can lowered significantly blood glucose levels (p<0,05) of
alloxan induced-diabetic mice, decreased urine volume (p<0,05), decreased
volume of drinking water (p<0,05), and did not affect relative organ weight
of heart, liver and kidney (p>0,05).
Keywords: alloxan,
antidiabetic, ethanol, Fibraurea tinctoria Lour, roots and stem
Penulis: Rahayu Utami, Nofri
Hendri Sandi, Syilfia Hasti, Sutri Delvia
Kode Jurnal: jpfarmasidd150621
