Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen -Urea
Abstrak: A research on the
study of physical and chemical stability of ketoprofen-urea solid dispersions.
Solid dispersions prepared through dissolution method with ketoprofen-urea
ratio is 1:1, 1:3, 1:5. Powder solid dispersion system was evaluated
physicochemical properties include analysis Differential Thermal Analysis
(DTA), FT-IR spectroscopy, and dissolution profiles. Accelerated stability test
for 3 months at a temperature (40±2)°C. The parameters tested include
organoleptic test and ketoprofen levels. Ketoprofen levels were measured by UV
spectrophotometer at a wavelength of 255.5 nm after being stored for 1, 2, and
3 months at a temperature (40±2)°C. DTA analysis results showed endothermic
peak shift ketoprofen meaningful. FT-IR spectra showed no chemical interaction
between ketoprofen-urea solid dispersion powder. The results showed that solid
dispersions of ketoprofen-urea can improve the physicochemical properties and
can enhance the dissolution profile of solid dispersion compared to pure
ketoprofen with the highest dissolution results indicated by solid dispersion
formula 3 (1:5) is 105.674%. Test chemical and physical stability of solid
dispersions of ketoprofen-urea showed a change in the physics and chemistry of
solid dispersions. Organoleptic test the change in color the three formulas.
While the test by the chemical assay,
the three formulas while showed that increasing the concentration of urea in
the solid dispersion of a decrease in the levels of ketoprofen. The most stable
formula is the formula 1 (1:1) to 24.748 months of age.
Kata Kunci: Ketoprofen; Urea;
Solid Dispersion; Physical and Chemical Stability
Penulis: Salman Umar, Monica
Selfia, Rieke Azhar
Kode Jurnal: jpfarmasidd140522
