Studi Farmakofor Reseptor COX-2 Sebagai Anti Inflamasi
ABSTRACT: Cyclooxygenase (COX)
receptor is a dual-function receptor that bound to the membrane which acts to
catalyze two important stages in the formation of prostanoide,namely
cyclooxigenation and peroxidation. Cyclooxigenation stage is the stage in whichCOX
cyclization process and the addition of two molecules of oxygen to arachidonic
acid toform prostaglandin G2 (PGG2). While the stage is the stage of the
reduction of theperoxidation of PGG2 endoperoxide become unstable compound
called prostaglandine H2(PGH2). The purpose of this study is to determine the
features that are important pharmacophore on anti-inflammatory activity of
compounds on COX-2 receptor. Modeling and determination pharmacophore features
created using the program MOE application version 2009 Virtual screening of
chemical compounds to look for natural ingredients inaccordance with
pharmacophore features that have been made. Molecular docking to study ligand-receptor
interactions, performed using MOE.
Keywords: COX-2 receptor, inflammation,
pharmacophore feature, virtual screening, docking molekuler
Penulis: Nursalam Hamzah,
Ahmad Najib, Nurshalati Thahir, Ika Misqawati
Kode Jurnal: jpfarmasidd130406
