SCREENING OF ACTIVE COMPOUNDS FROM Artemisia annua USING HFC-134A SUBCRITIC EXTRACTION SYSTEM
Abstract: Artemisia annua is
known as the source of artemisinin, a sesqueterpene lactone possessing
endoperoxide moeity with antiplasmodium activity. Sub-critical extraction of
artemisinin from Artemisia annua using R134a solvent was conducted. A close
system cycle process was constructed to investigate the ability of R134a to
extract artemisinin together with other active compounds. Artemisinin and other
isolated compouds yield was investigated at 30°C and presure process at 10
barr, with variation of process time. The extracted product was analysed as
artemisinin as the target compounds with several isolated compounds as by
product. Artemisinin content was reported ranging up to 0,5%, and the sub
critic system was reported to be more efficient and effective comparing to
other conventional extraction methods. The phytonics HFC-134a sub critics
process can be used for extraction in selected pharmacologically active
products from herbal plants.
Keywords: Artemisia annua,
HFC-134a sub critic, extraction
Penulis: Arthur Lelono, Sabar
Simanungkalit, Ibnu Umarudin, Herlan Herdiawan
Kode Jurnal: jpfarmasidd180033
