Potential of Red Spinach Leaves Ethanolic Extract (Amaranthus tricolor L.) as a Complementary Therapy For Hiperlipidemia: Study in Vivo of Histopathologic and Activity of Alanin Aminotransferase (ALT)
Abstrak: This study was
conducted to determine the potential of ethanolic extract of red spinachÂ
leaves (Amaranthus tricolor L.) with control quality as a complementary
treatment of hyperlipidemic based on histopathology and activity of alanin
aminotrasferase (ALT). A total of 24 male Wistar rats were randomized in 6
groups: normal group; positive control group were given the drug simvastatin;
negative control group; 1st treatment group was given extract at dose of
400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and
simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at
dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction
hyperlipidemic using high fat diet and poloxamer. The data obtained were tested
normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA
and Post-Hoc Tukey HSD to determine the significance of differences between
groups for ALT parameter. Result show the use of ethanolic extract of red
spinach leaves can reduce fatty liver condition based on decreased level of ALT
and liver histopathologic. It is concluded that the ethanolic extract of red
spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity
of ALT until 31.57 U1-1.
Kata Kunci: Amaranthus tricolor
L., Alanin Aminotransferase Hyperlipidemic, Complementary, Histopathologic
Penulis: Dimas Adhi Pradana,
Irna Destya Anggriani, Tri Ratna Setyaningrum
Kode Jurnal: jpfarmasidd160588
