Peningkatan Laju Disolusi Sistem Dispersi Padat Ibuprofen – PEG 6000
Abstrak: It has done research
on increasing the dissolution rate of solid dispersion system Ibuprofen with
polymer Polyethylenglycols 6000 (PEG 6000). Solid dispersion system prepared by
melting method with a ratio of raw materials Ibuprofen - PEG 6000, namely :
6:4, 7:3, 8:2, and 9:1. As a comparison was made with the physical mixture of
the same composition. The powder mixture of physics and solid dispersion system
properties of solids characterized by spectroscopic analysis, SEM analysis, DTA
analysis, and X-ray diffraction analysis. Dissolution test method is determined
by a basket. The results showed that the powder solid dispersion system can
improve the physicochemical properties of Ibuprofen. Dissolution profiles
showed that the 7:3 solid dispersion system powder in the 45th minute to
increase the dissolution rate compared to the powder mixture of physics.
Kata Kunci: Solid Dispersion System, ibuprofen, PEG 6000
Penulis: Auzal Halim, Elvi
Rahma Yulisman, Erizal Zaini
Kode Jurnal: jpfarmasidd130397
