PENGARUH KEMASAN TERHADAP AKTIVITAS ANTI BAKTERI SUSPENSI ERITROMISIN SETELAH PENYINARAN DENGAN SINAR MATAHARI LANGSUNG
Abstract: Erythromycin is a
type of antibiotic medication. The drug is unstable when in the water because
it can undergo hydrolysis process. Fortunately, it can be prevented by making dry
syrup dosage form. In addition to hydrolysis, erythromycin can also have
photolysis. For preventing the reaction, it can be done by packing the
medication in an opaque and tightly closed container. This research was
conducted to determine the effect of packaging on the stability of erythromycin
suspension that has been exposed to direct sunlight within a period. The
research was done by exposing erythromycin suspension, which was packed with
three kinds of color packaging namely brown, translucent, and opaque, for 30
minutes, 60 minutes, 90 minutes and 120 minutes, then continued by a
microbiological test with a diffusion method to determine the activity of
erythromycin against Staphylococcus Aureus. The results of the research showed
the existence of diameter of barrier areas around the spots that were given a
test solution. It means that the test solution has antibiotic activity against
bacteria. Preparations packaged in brown color have higher inhibition when
compared with the opaque and translucent. It shows that the erythromycin
suspension packaged in brown colors was more efficient in stabilizing the
preparation
Keywords: Erythromycin, Staphylococcus aureus ATCC 25923,
hydrolysis, dry syrup, suspension, photolysis, package, expose
Penulis: Nurul Hidayati
Kode Jurnal: jpfarmasidd160431
