PENGARUH EKSTRAK ETANOL DAUN JAMBU AIR (Syzygium aqueum (Burm f.)Alston) TERHADAP GLUKOSA DARAH, UREUM DAN KREATININ TIKUS PUTIH (Rattus norvegicus)
Abstract: Diabetes mellitus
with complications of Diabetic Nephropathy become one of the most common cause
of end-stage renal failure in the world. Impaired kidney function is measured
by Glomerular Filtration Rate (GFR). Where the decline in GFR was followed by
increased levels of blood glucose, urea and creatinine. This study aimed to
determine whether there is the content of secondary metabolites in leaves of
Sizygium aqueum leaf extract, at a dose of extract what impact the blood
glucose, urea and creatinine levels of male rats and whether the water extract
of guava leaves have an influence on the blood glucose, urea and creatinine
white male rats. This study uses a randomized block design with six treatment
groups consisting of five test animals. Group I was normal control (CMC Na
suspension 0.5%). Group II negative control (streptozotocin 40 mg/kg). positive
control group III (suspension glibenclamide). Group IV given guava leaf extract
100 mg/kg BW. V group awarded guava leaf extract 200 mg/kg BW. Group VI given
guava leaf extract 300 mg/kg BW. Treatment was given for 28 days and measured
levels of blood glucose urea and creatinine on days 0, 7, 14, 21 and 28. The
results showed nefroprotektif effect on all groups and most effective extract
are a group of guava leaf extract 100 mg/kg BW).
Keywords: Diabetic
nephropathy, urea, creatinine, Syzygium aqueum
Penulis: Joni Tandi
Kode Jurnal: jpfarmasidd170172
