Mikroenkapsulasi Metronidazol Dengan Polimer Hpmc Menggunakan Metoda Penguapan Pelarut
Abstrak: Microencapsulation of
metronidazole using HPMC as a polymer by solvent evaporation method had been
studied. Microcapsulhad been made into3formulation with 3 ratio variation
between Metronidazole and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were analyzed by
SEM, DTA, FT-IR, particle sized distribution and dissolution profile.
Microcapsules were white to slightly yellow and almost perfectly
spherical.Disolution profiles of microcapsules showed that the greater amount
of HPMC gave the slower release ofMetronidazole. Dissolution kinetics of
microcapsule allowedHiguchi equation, where the realese of Metronidazole from microcapsules were controlled by
diffution process.
Kata Kunci: Microencapsulation,
Metronidazole and HPMC
Penulis: Auzal Halim, Reni
Daniati, Rina Wahyuni
Kode Jurnal: jpfarmasidd130393
