Mikroenkapsulasi Karbamazepin dengan Polimer HPMC Menggunakan Metoda Emulsifikasi Penguapan Pelarut
Abstrak: Microencapsulation of
Carbamazepine using HPMC as a polymer by emulsification solvent evaporation
method had been studied. Microcapsules had been made into 3 formulation with 3
ratio variation between Carbamazepine and HPMC, 1:1; 1:1.5; 1:2. Microcapsules
were evaluated by SEM, DTA, FT-IR, particle sized distribution, drug content
and dissolution profile. The evaluation result showed that HPMC as a polymer of
sustained release was influence characteristic microcapsules of Carbamazepine.
Microcapsules were white to slightly yellow and almost perfectly spherical.
Disolution profiles of microcapsules showed that the formula containing the
greatest amount of HPMC gave the slower release of Carbamazepine. Resistance
release of biggest drug shown by formula 3 giving disolution during 6 hour
counted 24.5296 %. Dissolution kinetics of microcapsules allowed Higuchi
equation, where the realese of Carbamazepine
from microcapsules were controlled by diffution process.
Kata Kunci: Microencapsulation;
Carbamazepine; HPMC
Penulis: Rina Wahyuni, Auzal
Halim, Yustina Susi Irawati
Kode Jurnal: jpfarmasidd150617
