Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico
Abstract: Dendrimers are a
class of highly branched synthetic polymers that has spherical form consist of
three components: core, branch and terminal functional groups. One of dendrimer
that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used
as a template in the preparation of gold nanoparticles. This research was
studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation
4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers
generation 4 downloaded from Building Toolkit (DBT) Library and before the
simulation structure was prepared. Then molecular dynamics simulations run
using the AMBER program at 37°C in aqueous conditions. From analysis, obtained
that the furthest distance of streched cavities at the closest distance from
the core, region between residues 2 and 3 is 23.696 Å and at the terminal
region between residues 100 and 122 is 58.045
Kata Kunci: Dendrimer, PAMAM, nanopartikel, in silico
Penulis: Yurika Sastyarina, Zuhrotun
Nafisah, Muhammad Yusuf, Martalena Ramli, Abdul Mutalib, Ukun Soedjanaatmadja
Kode Jurnal: jpfarmasidd170168
