Hypoglycemic Activity and Pancreas Protection of Combination Juice of Mengkudu (Morinda citrifolia Linn.) Juice and Temulawak (Curcuma xanthorrhiza Roxb.) Juice on Streptozotocin-Induced Diabetic Rats
Abstract: Mengkudu fruit
contains scopoletin and temulawak rhizome contains curcumin have been observed
because they have strong antioxidant activity and they were used traditionally
as antidiabetic. This research aimed to evaluate effect of antihyperglycemic
and pancreas protection of juice combination of mengkudu fruit juice (MFJ) and
temulawak rhizome juice (TRJ) on diabetes rats which were inducted with
streptozotocin (STZ). Rats were grouped into 7 groups, each of group consisting
5 rats. Each of group was treated accordingly for 28 days except for a normal
group of rats. Rats taken blood from the plexus retroorbitalis for examination
of blood glucose levels every week. On the last day, rats blood was examined
for malondialdehyde (MDA) levels. After that the rats were turned off for
examination of pancreatic morphological conditions. The results showed that diabetic
rats given MFJ-TRJ combination juice experienced a significant decrease in
blood glucose levels, a significant decrease in MDA levels and improvement
pancreas morphology when compared with the negative control group. The
conclusion of this research was giving combination juice of MFJ-TRJ juice can
decreased blood glucose level, decreased MDA level and can improved pancreas
morphology condition.
Keywords: hypoglycemic,
pancreas protection, combination juice, mengkudu, temulawak
Author: Bilal Subchan Agus
Santoso, Sudarsono, Agung Endro Nugroho, Yosi Bayu Murti
Jurnal Code: jpfarmasigg180004
