GAMBARAN HISTOPATOLOGI ORGAN HATI DAN GINJAL MENCIT BALB/C SETELAH PEMBERIAN KRIM EKSTRAK TEH HIJAU (CAMELLIA SINENSIS L.)
ABSTRACT: Development of green
tea extract formulation with the addition of enhancers to increase the ability
of epigallocatechin gallate to penetrate the skin layers has been done.
Objective: The purpose of this study was to determine the effect of green tea
extract cream that containing enhancers on the profile of kidney and liver
histopathology. Methods: The study used 4 groups which each group was treated
with different concentrations of extract (2,0%; 2,5%; 3,0%; 3,5%) and 1 control
group. After 24 hours and 14 days of application of the cream, the mice were
sacrificed. The liver and kidneys were weighed and made preparations
histopathology. Results: The results of the study showed that there similar
(p>0,05) of the weight ratio of the liver and kidneys of Balb/c mice after
24 hours and 14 days. As well the histopathological test indicated that there
similar (p>0,05) of the liver and kidneys after 24 hours and 14 days of
administration of green tea extract cream. Conclusions: The levels
concentration of green tea extract in cream (2,0%; 2,5%; 3,0%; 3,5%) that
contain enhancers do not affect the liver and kidney histopathological of
Balb/c mice.
KEYWORDS: Camellia sinensis L,
histopathology, liver, kidney, enhancer
Penulis: Nining Sugihartini, M
Alif Fajri
Kode Jurnal: jpfarmasidd160730
