Formulation and Evaluation of Glipizide Tablets Utilizing Hibiscus Rosasinensis Leaves Mucilage
Abstract: This research work
aims to develop glipizide tablets using Hibiscus rosasinensis leaves mucilage.
The mucilage was extracted by using double distilled water and precipitated
with ethanol. The precipitated mucilage was dried and grounded into powder. The
tablet utilizing the mucilage as excipient was prepared by wet granulation
method. The tablets were subjected to various tests. The evaluatory parameters
of tablets were found to be within the limits as per United States
Pharmacopoeia NF 24/19. FTIR spectrum reveals that there is no incompatibility
between the ingredients used. Diabetes was induced in wistar albino rats using
streptozotocin and effect of formulation on blood glucose level was determined.
It was observed that the formulation could not sustain the release of
glipizide. However, the glipizide release was retarded as the amount of
mucilage was increased. It was observed that on the completion of antidiabetic
study, the formulation could bring the blood glucose level to normal in group
rats. However, the blood glucose level was still elevated in group administered
with pure gliplizide. It can be concluded that HRM can be used to formulate
glipizide tablets. The formulations with HRM shows better hypoglycemic activity
and this may be attributed to antidiabetic activity of Hibiscus rosasinensis.
Author: Sanjib Bahadur, Amit
Roy, Pragya Baghel, Ananta Choudhury, Suman Saha, Ranabir Chanda
Journal Code: jpfarmasigg180001
