FORMULASI, KARAKTERISASI DAN UJI PENETRASI IN VITRO PATCH EKSTRAK BIJI KOPI ROBUSTA (COFFEA CANEPHORA) SEBAGAI SEDIAAN ANTI SELULIT
Abstrak: Cellulite is a very
common topographical alteration in which the skin acquires an "orange
peel". Caffeine is the classification which can be used as an
anti-cellulite in patch. The basic material used is Robusta coffee bean extract
(Coffea canephora), which has a high caffeine content. This study aimed to
knowing how much Chitosan polymer and HPMC ratio which can produce a patch with
the characteristics and good penetration and show its releasing profile. Patch
madewith chitosan concentrations : HPMC1:1 (formula I), 2:1 (formula II), and
1: 2 (formula III) by increasing in glycerin as plastizier and Tween 80, penetration
enhancers used solvent casting method. The penetration ability was tested as in
vitro by Franz diffusion instrument modified in using the human cadaver skin.
Penetration test performed for two hours with sampling in the minute, 5 10, 15,
45, 60, 90 and 120. Each sampling measured on UV-Vis spectrophotometer. The
results obtained were the three formulasy characteristics of a good patch with
the varying releasing profiles. Formula I and II showed the Higuchi’s releasing
profile, while the formula III showed zero-order releasing profile.
KATA KUNCI: Cellulite.,
Caffeine., Patch., In Vitro Penetration Testing., Releasing Profil
Penulis: Surya Ningsi, Naswina
Putrianti, Dwi Wahyuni
Kode Jurnal: jpfarmasidd140538
