EVALUATION OF SYNERGISTIC EFFECT OF Kaempferia galanga L. RHIZOME EXTRACTS ON THE ANTIBIOTIC ACTIVITY ANTIBIOTICS AGAINST BACTERIAL PATHOGENS
Abstract: Background: aromatic
ginger rhizome (Kaempferia galanga L.) is a member of Zingiberaceae family, has
been known to have an antibacterial effect is used for everyday cooking spices,
but the synergistic effect on broad spectrum antibiotics was unknown.
Objective: this research was conducted to find out the synergistic effect of
Kaempferia galanga L. Rhizome extract (KGR) on some broad-spectrum antibiotics
against gram positive and negative bacterial pathogens in vitro. Method: KGR
was taken from farmers in Samarinda City, East Kalimantan Province, Indonesia.
Extraction by maceration with ethanol solvent. Antibacterial activity test of
KGR ethanol extract, antibiotic and synergistic effect using Mueller-Hinton
agar, Kirby-Bauer disc diffusion method on ampicillin, cefuroxime,
chloramphenicol, ciprofloxacin, and meropenem antibiotics against
Staphylococcus aureus and Escherichia coli. Results were expressed in
percentage increase of the inhibition zone. Statistical test with t-test,
significantly different if p<0.05. Results: KGR ethanol extract showed
increase the percentage of antibiotic inhibition zone, ampicillin being the highest
and the weakest of ciprofloxacin in E. coli; meropenem being the highest and
the weakest of ciprofloxacin in S. aureus, statistically significant different
tests on antibiotic ampicillin (E. coli), meropenem and cefuroxime. Conclusion:
KGR ethanol extract showed synergistic effect on antibiotic ampicillin (E.
coli), meropenem and cefuroxime in S. aureus and E. coli.
Keywords: Kaempferia galanga,
synergistic, antibiotic, Escherichia coli, Staphylococcus aureus
Penulis: Almira Fahrinda
Kode Jurnal: jpfarmasidd180031
