Efficacy of Bacillus clausii and Saccharomyces boulardii in Treatment of Acute Rotaviral Diarrhea in Pediatric Patients
Abstract: Diarrhea disease is
considered as major health problem in developing countries. Rotavirus is the
most common identifiable viral cause of diarrhea in all children and belongs to
Reoviridae family. Rotavirus infection occasionally leads to severe dehydration
in infants and children. The objective of the study is to assess the efficacy
of Bacillus clausii and Saccharomyces boulardii on the treatment of rotaviral
diarrhea, and also to assess its effect on vomiting and fever in pediatric
patients. This study conducted at Rainbow Children’s Hospital, Hyderabad,
India, from January 2016 until June 2016 and adopts prospective observational
parallel study design. From 104 patients enrolled, 80 fulfilled inclusion
criteria and 24 were excluded from the study. Patients were divided into two
groups based on the treatment. Group I patients were treated with Bacillus
clausii and Group II patients were treated with Saccharomyces boulardii. Total
mean duration of diarrhea was significantly shorter in Group II (S. boulardii)
in comparison with Group I (B. clausii). S. boulardii significantly (p≤0.005)
decreased the duration of diarrhea which is 25.2 hours over B. clausii. Both
probiotic preparations were equal in efficacy on treating the vomiting and
fever (p≥0.005). S. boulardii and B. clausii were well accepted.
Keywords: Bacillus clausii;
Probiotics; Rotaviral diarrhea; Saccharomyces boulardii
Penulis: Salloju Vineeth,
Shagamreddy Saireddy, Thallapalli Keerthi, Prasantha Kumari Mantada
Kode Jurnal: jpfarmasidd170010
