Effect Of Ethanol Extract Of Kenikir (Cosmos caudatus Kunth.) Leaves in Blood Glucose, Cholesterol and Histopathology Pancreas of Male White Rats (Rattus norvegicus)
Abstrak: The aim of this study
was to investigate the effects extract of Kenikir in male rats parameters blood
glucose, cholesterol and histopathological of the pancreas. Thirty rats were
divided into six groups, and each group consists of five individuals with the
details of groups I, II, and III as control groups and groups IV, V, and VI for
the experiments. Group I: normal control was given NaCMC 0,5%; Group II:
control negative was given Streptozotocin 30 mg/kgBW i.p, high feed fat 25
g/day, and the positive control was given met form in 45 mg/kgBW, and the
experimental groups were each given extract of the kenikir leaves with dose 100
mg/kg BW, 200 mg/kgBW , and 400 mg/kg BW. The results showed that there were
secondary metabolites contained in the extract of leaves of kenikir. Giving the
extract of kenikir leaves at the dose of 200 mg/kg is effective in lowering the
blood glucose levels, extract of leaves of kenikir with the dose of 400 mg/kg
is effective to reduce the total cholesterol levels and regenerate pancreatic
tissue, and extract of leaves of kenikir with the dose of 100 mg/kg BW did not
give any maximum impacts to decrease the blood glucose.
Keywords: Cholesterol,
diabetic, histopathology, kenikir leaves ethanol extract
Penulis: Joni Tandi, Jong A. Claresta,
Gusti Ayu, Irwan
Kode Jurnal: jpfarmasidd180237
