Efek Nefroprotektif Kombinasi Ekstrak Daun Gedi Merah dan Daun Kumis Kucing pada Tikus Induksi Etilen Glikol
Abstract: Nephroprotective
compound is a compound that has the ability to protect the kidneys from kidney
disorders caused by free radicals. This research aimed to determine the
nephroprotective effect of the combination of Abelmoschus manihot leaves and
Orthosiphon stamineus leaves extract as well as to know the effective extract
dose combinations as nephroprotective. This research applied Group Random
Design with 6 treatment groups consists of 5 tested animals. Group I was normal
control. Group II was negative control.
All extract groups was given 0,75% of ethylene glycol and 2% of ammonium
chloride. Group III was given 100 mg/kg BW of Abelmoschus manihot leaves
extract and 200 mg/kg BW of Orthosiphon stamineus leaves extract. Group IV was
given 50 mg/kg BW of Abelmoschus manihot leaves extract and 100 mg/kg BW of
Orthosiphon stamineus leaves extract. Group V was given 100 mg/kg BW of
Abelmoschus manihot leaves extract. Group VI was given 200 mg/kg BW of
Orthosiphon stamineus leaves extract. Treatment was given for 14 days and the
levels of creatine and urea were measured on day 0, 8 and 15. The results show
the nephroprotective effect in all the extract groups, but the most effective
one was the group III.
Keywords: Nefroprotective,
ethylene glycol, Abelmoschus manihot, Orthosiphon stamineus
Penulis: Joni Tandi, Moh. Roem,
Yuliet Yuliet
Kode Jurnal: jpfarmasidd170166
