EFEK ANTIPIRETIK KOMBINASI EKSTRAK DAUN COCOR BEBEK (Kalanchoe pinnata L.) DAN EKSTRAK DAUN TEMBELEKAN (Lantana camara L.) PERS.TERHADAP MARMUT (Cavia porcellus) DENGAN DEMAM YANG DIINDUKSI PEPTON
Abstract: Cocor Bebek (Kalanchoe
pinnata L.) is a medicinal plant that has been used as traditional medicine for
long period, used to fight fever, but it empirically leaves of Tembelekan (Lantana camara L.) are also
generally primarily used to treat fever. Research on the effects of the
combination of Cocor Bebek’s leaf extract (Kalanchoe pinnata L.) and the leaf
extract of tembelekan (Lantana camara L.) Pers on male guinea pig (Cavia
porcellus) is induced peptone 5% at a dose of 150 mg / kg body weight. With the
aim to determine the effect of the combination and determine the effects of the
most effective as an antipyretic. Extracts prepared by maceration method using
ethanol 95%. Marmots were divided into 4 groups. Each guinea pig was induced
using peptone 5%. The first group was given Na CMC as a negative control group
2nd given a combination of one dose combinations (50 + 720). Group 3 was given
a second dose combination (100 + 720). Group-4 were given a 3-dose combination
(150 + 720). Temperature measurement is carried out for 2 hours with a 30
minute interval. Data were analyzed temperature measurements were statistically
analyzed using ANOVA (Analisys Of Variance). The research result was
addressing, that the combination of extracts can reduce fever. The combination
is most effective as an antipyretic is cocor duck leaf extract 50 mg and 720 mg
tembelekan leaf extract (50 + 720).
Keywords: Tembelekan; Cocor
bebek; Antipyretic; Peptone
Penulis: Heni Purwitasari,
Yuliet, Ihwan
Kode Jurnal: jpfarmasidd170558
