AKTIVITAS ANTIOKSIDAN SENYAWA KUMARIN TER-O-GERANILASI DARI AKAR Limonia acidissima L.
Abstract: Five O-geranylated
coumarins namely as auraptene (1),
7-((2’E,6’E)-5’-hydroxy-3’,7’-dimethylocta-2’,6’-dienyloxy)coumarin (2),
7-(2’E,5’E)-7’-hydroxy-3’,7’-dimethylocta-2’,5’-dienyloxy) coumarin (3),
6-methoxy-7-oxygeranylcoumarin (4), and 8-oxygeranylpsoralen (5) were isolated
from the roots of Limonia accidissima
L. Their structures were determined based on spectroscopic data such as UV, IR,
MS and NMR. Compounds 1–5 were evaluated for their radical scavenging against
2,2-diphenyl-1-picrylhydrazyl (DPPH), showing their IC50 were 462; 13; 260; 210
and 234 µg/ml, respectively.
Keywords: Limonia accidissima
L., O-geranylated coumarins, antioxidant
activity, DPPH
Penulis: Tjitjik Srie Tjahjandarie,
Ratih Dewi Saputri, Mulyadi Tanjung
Kode Jurnal: jpfarmasidd170175
